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Ziprasidone: Quiz

  

Question 1:
How is Ziprasidone excreted?
Urine and feces
10-15% unchanged
70-90% unchanged in urine, 1.3ml/kg/min t1/2 2- 4 hours
faecal 47%

Question 2: [5][6] Antagonism at histaminic and alpha adrenergic receptors likely explains some of the side effects of ziprasidone, such as sedation and ________.
HypertensionPulmonary hypertensionOrthostatic hypotensionHypotension

Question 3: Recently, the FDA required the manufacturers of some atypical antipsychotics include a warning about the risk of hyperglycemia and ________ with atypical antipsychotics.
Diabetes mellitus type 2Anti-diabetic drugInsulin therapyDiabetes mellitus

Question 4:
What is the molecular weight of Ziprasidone?
358.842 g/mol
412.936
466.551 g/mol
414.496 g/mol

Question 5: Ziprasidone has a high affinity for dopamine, serotonin, and ________ and a moderate affinity for histamine receptors, where it is believed to act as an antagonist.
Alpha-1 adrenergic receptorAdrenergic receptorDopamine receptor D4Alpha-2 adrenergic receptor

Question 6:
What is the chemical name of Ziprasidone (IUPAC)
6-chloro-1,3-dihydro-2H-indol-2-one
N-2-(1H-indol-3-yl)ethyl-N-methylpropan-2-amine
3-2-(diisopropylamino)ethyl-1H-indol-4-ol
N,N-dimethyl-2-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-ylethanamine

Question 7: Some evidence suggests that ziprasidone may not be as bad as some of the other atypical antipsychotics (namely, olanzapine (Zyprexa)) at causing ________ and weight gain.
Diabetes mellitusDiabetic ketoacidosisInsulin resistanceEndocrine system

Question 8: In addition to its antipsychotic use, ziprasidone is sometimes prescribed for the treatment of ________ disorders.
Obsessive–compulsive disorderHypochondriasisTicSocial anxiety disorder

Question 9:
Ziprasidone, Indigo dye and Ropinirole are all:
Pfizer Piperazines Indolines Lactams

Question 10: Ziprasidone (marketed as Geodon, Zeldox by ________) was the fifth atypical antipsychotic to gain FDA approval (February 2001).
PfizerAmerican ExpressJohnson & JohnsonMerck & Co.
















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