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Von Willebrand factor: Quiz

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Question 1: vWF is a large multimeric glycoprotein present in blood plasma and produced constitutively in endothelium (in the Weibel-Palade bodies), ________ (α-granules of platelets), and subendothelial connective tissue.
White blood cellMast cellMegakaryocyteEosinophil granulocyte

Question 2: It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly ________.
Escherichia coli O157:H7Waterhouse-Friderichsen syndromeHemolytic-uremic syndromeBartonellosis

Question 3: Although von Willebrand could not identify the definite cause, he distinguished von Willebrand disease (vWD) from ________ and other forms of bleeding diathesis.
Haemophilia AFanconi anemiaSickle-cell diseaseHaemophilia

Question 4: The basic vWF monomer is a 2050 ________ protein.
MetabolismAmino acidL-DOPAAmino acid synthesis

Question 5: Von Willebrand factor is not an ________ and therefore has no catalytic activity.
ProteinEnzymeCofactor (biochemistry)Enzyme inhibitor

Question 6: vWF binds to other platelet receptors when they are activated, e.g., by ________ (i.e., when coagulation has been stimulated).
ThrombinPlasminTissue plasminogen activatorFactor X

Question 7: the D'/D3 domain, which binds to ________
PlasminFactor VIIIAntithrombinFactor X

Question 8: Multimers of vWF can be extremely large, >20,000 ________, and consist of over 80 subunits of 250 kDa each.
Atomic mass unitAtomic massHydrogenAtom

Question 9: With respect to the glycosylation, vWF is one of the few proteins that carry ________ antigens.
Kell antigen systemBlood typeDuffy antigen systemABO blood group system

Question 10: Monomers are subsequently N-glycosylated, arranged into dimers in the endoplasmic reticulum and into multimers in the ________ by crosslinking of cysteine residues via disulfide bonds.
Cell (biology)Cell nucleusGolgi apparatusLysosome







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