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Von Willebrand disease: Quiz


Question 1: Acquired vWD has also been described in the following disorders: Wilms' tumour, ________ and mesenchymal dysplasias.
HypopituitarismHypothyroidismGraves' diseaseHashimoto's thyroiditis

Question 2: Women may experience heavy menstrual periods and blood loss during ________.
Breech birthMiscarriageChildbirthEctopic pregnancy

Question 3: Micro-: ________ (Plummer-Vinson syndrome)
Sickle-cell diseaseIron deficiency anemiaSerum ironHenoch–Schönlein purpura

Question 4: A platelet function assay (PFA) will give an abnormal collagen/________ closure time and in most cases (but not all) a normal collagen/ADP time.

Question 5: A form of vWD occurs in patients with ________, leading to gastrointestinal bleeding (Heyde's syndrome).
Mitral regurgitationAortic valve stenosisMitral stenosisAortic insufficiency

Question 6: It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for ________ adhesion.
Red blood cellBlood plasmaPlateletBlood

Question 7: von Willebrand disease (vWD) is the most common hereditary ________ abnormality described in humans, although it can also be acquired as a result of other medical conditions.
FibrinolysisTissue plasminogen activatorPlateletCoagulation

Question 8:, International repository on vWF mutations (________)
University of LeedsSheffield Hallam UniversityUniversity of YorkUniversity of Sheffield

Question 9: Trouble may arise in the form of bleeding following surgery (including dental procedures), noticeable easy bruising, or ________ (heavy periods).
DysmenorrheaPremenstrual syndromeMenorrhagiaAmenorrhoea

Question 10: It may be more severe or apparent in people with ________ O.
Hematologic diseaseRh diseasePreterm birthBlood type


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