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Verapamil: Quiz

  

Question 1:
How is Verapamil excreted?
Renal: 11%
Renal ; Faeces
Renal, mostly unchanged
Renal, faecal

Question 2:
What is the elimination half life of Verapamil?
4 hours ,
5 to 7 hours
1.14-1.24 hours
2.8-7.4 hours

Question 3:
What is the chemical name of Verapamil (IUPAC)
1'--1--1,2-dihydrospiroindole-3,4'-piperidine
6-chloro-3--1,1-dioxo-3,4-dihydro-2H-benzoe1,2,4thiadiazine-7-sulfonamide
-2--5-[2-(3,4-dimethoxyphenyl)ethyl-
N-4-(2-Dimethylaminoethoxy)phenyl]methyl]-3,4-dimethoxybenzamide

Question 4: Verapamil (brand names: Isoptin, Verelan, Verelan PM, Calan, Bosoptin, Covera-HS) is an L-type calcium channel blocker of the ________ class.
AlcoholPyridineAmineAmide

Question 5: It has been used in the treatment of hypertension, ________, cardiac arrhythmia, and most recently, cluster headaches.
Myocardial infarctionAtherosclerosisCoronary artery diseaseAngina pectoris

Question 6: Verapamil is also used in cell biology as an inhibitor of drug efflux pump proteins such as ________.
ABCG2P-glycoproteinBand 3RHAG

Question 7: This has led to their use in treating hypertension and ________.
Coronary artery diseaseAngina pectorisAtherosclerosisMyocardial infarction

Question 8: It is a class 4 antiarrhythmic, more effective than ________ in controlling ventricular rate, and was approved by the United States Food and Drug Administration in 1981.
DigoxinLidocaineAmiodaroneProcainamide

Question 9: In cardiac pharmacology, calcium channel blockers are considered class IV ________.
Antihypertensive drugBeta blockerAntiarrhythmic agentAntianginal

Question 10: Verapamil has also been used as a ________ during cryopreservation of blood vessels.
VasodilationAntianginalBeta blockerCalcium channel blocker
















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