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Tyrosine kinase: Quiz

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Question 1: Tyrosine kinases are a subgroup of the larger class of ________.
GlucokinaseAspartokinaseProtein kinaseHexokinase

Question 2: In every case, the result is a hyper-active kinase, that confers an aberrant, ligand-independent, non-regulated growth stimulus to the ________ cells.
ChemotherapyMetastasisCarcinogenesisCancer

Question 3: A tyrosine kinase is an ________ that can transfer a phosphate group from ATP to a tyrosine residue in a protein.
Enzyme kineticsEnzyme inhibitorEnzymeCofactor (biochemistry)

Question 4: The first non-receptor tyrosine kinase identified was the v-src ________ protein.
Tumor suppressor geneCancerCarcinogenesisOncogene

Question 5: ________ (brand names Gleevec and Glivec) is a drug able to bind the catalytic cleft of these tyrosine kinases, inhibiting its activity.
SildenafilDasatinibClozapineImatinib

Question 6: In particular, movement of some parts of the kinase domain gives free access to ________ (ATP) and the substrate to the active site.
Adenosine monophosphateCytidine triphosphateAdenosine triphosphateAdenosine diphosphate

Question 7: Tyrosine kinases are particularly important today because of their implications in the treatment of ________.
CarcinogenesisMetastasisChemotherapyCancer

Question 8: ________ of proteins by kinases is an important mechanism in signal transduction for regulation of enzyme activity.
Amino acidPosttranslational modificationUbiquitinPhosphorylation

Question 9: This triggers a cascade of events through ________ of intracellular proteins that ultimately transmit ("transduce") the extracellular signal to the nucleus, causing changes in gene expression.
UbiquitinPosttranslational modificationPhosphorylationAmino acid

Question 10: At present, 58 ________ (RTKs) are known, grouped into 20 subfamilies.
ErbBReceptor tyrosine kinaseRET proto-oncogenePlatelet-derived growth factor receptor







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