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Thymus: Quiz


Question 1: By the early teens, the thymus begins to atrophy and thymic stroma is replaced by ________ (fat) tissue.
Brown adipose tissueCollagenAdipocyteAdipose tissue

Question 2: If these peripheral tolerance mechanisms also fail, ________ may arise.
HypersensitivityAutoimmune diseaseAutoimmunityCell-mediated immunity

Question 3: ________ is an autoimmune disease caused by antibodies that block acetylcholine receptors.
Coeliac diseaseMyasthenia gravisSystemic lupus erythematosusAsthma

Question 4: These mice are an important model of primary ________ deficiency.
Cytotoxic T cellT helper cellRegulatory T cellT cell

Question 5: [7] Patients with the autoimmune disease ________ commonly (70%) are found to have thymic hyperplasia or malignancy.
Coeliac diseaseMyasthenia gravisAsthmaSystemic lupus erythematosus

Question 6: Cells in the thymus can be divided into thymic stromal cells and cells of ________ origin (derived from bone marrow resident hematopoietic stem cells).
Adaptive immune systemHaematopoiesisIdiopathic thrombocytopenic purpuraImmune system

Question 7: Developing T-cells are referred to as ________ and are of hematopoietic origin.
ThymocyteAdaptive immune systemImmune systemHaematopoiesis

Question 8: Upon atrophy, the size and activity are dramatically reduced, and the organ is primarily replaced with ________ (a phenomenon known as "organ involution").
FatFatty acidLipidTrans fat

Question 9: The cortex is the location of the earliest events in ________ development, where T cell receptor gene rearrangement and positive selection takes place.
ThymocyteHaematopoiesisImmune systemAdaptive immune system

Question 10: The ________ supplying the thymus are derived from the internal mammary, and from the superior thyroid and inferior thyroids.
Blood vesselArterial treeArterySystemic circulation


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