Thrombin: Quiz

Question 1: Thrombin bound to thrombomodulin activates ________, an inhibitor of the coagulation cascade.
Protein SProtein CPlasminFactor X

Question 2: Crohn's disease or Ulcerative Colitis) and prothrombin mutation or ________ Leiden mutation have been contradicted by research.
Protein SFactor VFactor XFactor VII

Question 3: After the description of ________ and fibrin, Alexander Schmidt hypothesised the existence of an enzyme that converts fibrinogen into fibrin in 1872.

Question 4: Anti-thrombin antibodies in autoimmune disease may be a factor in the formation of the lupus anticoagulant also known as (________).
ThrombophiliaVon Willebrand diseaseThrombotic thrombocytopenic purpuraAntiphospholipid syndrome

Question 5: It is a serine protease (EC that converts soluble fibrinogen into insoluble strands of ________, as well as catalyzing many other coagulation-related reactions.
AntithrombinPlasminFibrinProtein C

Question 6: Prothrombin complex concentrate and ________ are prothrombin-rich coagulation factor preparations that can be used to correct deficiencies (usually due to medication) of prothrombin.
PlateletBloodFresh frozen plasmaBlood plasma

Question 7: The activity of factor Xa is greatly enhanced by binding to activated ________ (Va), termed the prothrombinase complex.
Protein SFactor VProtein CFactor VII

Question 8: In addition to its activity in the coagulation cascades, thrombin also promotes ________ activation, via activation of protease-activated receptors on the platelet.
BloodPlateletBlood plasmaRed blood cell

Question 9: Thrombin, a potent vasoconstrictor and mitogen, is implicated as a major factor in vasospasm following ________.
Intracranial hemorrhageCerebral hemorrhageStrokeSubarachnoid hemorrhage

Question 10: Deficiency of vitamin K or administration of the anticoagulant ________ inhibits the production of gamma-carboxyglutamic acid residues, slowing the activation of the coagulation cascade.

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