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Theophylline: Quiz

  

Question 1:
What is the chemical name of Theophylline (IUPAC)
-7-Acetyl-5--8,9-dihydro-8-methyl-7H-1,3-dioxolo4,5-h 2,3benzodiazepine
9,10-dihydro-7H-tetracene-5,12-dione
6,7-dimethyl-2,4-dipyrrolidin-1-yl-7H-pyrrolo2,3-dpyrimidine
1,3-dimethyl-7H-purine-2,6-dione

Question 2:
What is the elimination half life of Theophylline?
5-8 hours
8-42 hours
8-30 hrs
Tablet: 6-8 hours; IV: 5.5 hours

Question 3: [18] (________ switch off the inflammatory response by blocking the expression of inflammatory mediators through deacetylation of histones, an effect mediated via histone deacetylase-2 (HDAC2).
GlucocorticoidSex steroidCorticosteroidMineralocorticoid

Question 4: Theophylline, also known as dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as COPD or ________ under a variety of brand names.
Hypersensitivity pneumonitisFarmer's lungAllergic bronchopulmonary aspergillosisAsthma

Question 5: Clearance of the drug is increased in these conditions: children 1 to 12, teenagers 12 to 16, adult smokers, elderly smokers, ________, hyperthyroidism.
Malignant hyperthermiaCoeliac diseasePneumoniaCystic fibrosis

Question 6: As a member of the xanthine family, it bears structural and pharmacological similarity to ________.
CaffeineMethylphenidateMethamphetamineAmphetamine

Question 7: ________ in caffeine is also important in the infant population.
AcetylationMethylationAmino acidPosttranslational modification

Question 8: [7] Theophylline's first clinical use came in 1902 as ________.
Calcium channel blockerDiureticBeta blockerAntihypertensive drug

Question 9: A clinical study reported in 2008 that theophylline was helpful in improving the sense of smell in study subjects with ________.
Vertigo (medical)AnosmiaHallucinationAmnesia

Question 10: ________ stimulatory effect mainly on the medullary respiratory center.
Grey matterCentral nervous systemWhite matterNeuron
















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