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Thalassemia: Quiz


Question 1: In 2008, in ________, a baby was selectively implanted in order to be a cure for his brother's thalassemia.

Question 2: In Europe, the highest concentrations of the disease are found in ________ and in parts of Italy, in particular, Southern Italy and the lower Po valley.

Question 3: The child was born from an embryo screened to be free of the disease before implantation with ________.
Artificial inseminationPregnancyAssisted reproductive technologyIn vitro fertilisation

Question 4: This is probably by making the red blood cells more susceptible to the less lethal species Plasmodium vivax, simultaneously making the host's red blood cell (RBC) environment unsuitable for the merozoites of the more lethal strain ________.
Plasmodium ovaleMalariaCryptosporidiosisPlasmodium falciparum

Question 5: Thalassemia is a quantitative problem of too few globins synthesized, whereas ________ (a hemoglobinopathy) is a qualitative problem of synthesis of an incorrectly functioning globin.
HaemophiliaHemolytic anemiaSickle-cell diseaseGlucose-6-phosphate dehydrogenase deficiency

Question 6: There are also prevalences in descendants of people from ________ and Mediterranean countries (e.g.
Latin AmericaLatin American cultureAmericasSouth America

Question 7: Thalassemia patients produce a deficiency of either α or β globin, unlike ________ which produces a specific mutant form of β globin.
HaemophiliaSickle-cell diseaseGlucose-6-phosphate dehydrogenase deficiencyAnemia

Question 8: Treatment for patients with thalassemia major includes chronic ________ therapy, iron chelation, splenectomy, and allogeneic hematopoietic transplantation.
Transfusion reactionBlood transfusionIntraoperative blood salvageBlood donation

Question 9: There are an estimated 1,000 people living with ________ in the United States and an unknown number of carriers.
AnemiaBeta-thalassemiaFanconi anemiaSickle-cell disease

Question 10: ________, Italy, Portugal, Spain, and others).


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