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Terfenadine: Quiz

  

Question 1: Terfenadine is a prodrug, generally completely metabolised to the active form fexofenadine by the intestinal cytochrome P450 ________ isoform.
CYP3A4CYP2E121-HydroxylaseCYP2D6

Question 2: It was superseded by fexofenadine in the 1990s due to the risk of cardiac ________ caused by QT interval prolongation.
Myocardial infarctionSupraventricular tachycardiaAtrial fibrillationCardiac dysrhythmia

Question 3: Terfenadine appears in larger concentrations in plasma leading to toxic effects on the heart's rhythm and electrical conduction like ________ and torsades de pointes.
Myocardial infarctionVentricular tachycardiaHypertrophic cardiomyopathyAtrial fibrillation

Question 4: Toxicity is possible after years of continued use with no previous problems as a result of an interaction with other medications such as ________, or foods like grapefruit.
MinocyclineErythromycinTetracyclineClindamycin
















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