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Tadalafil: Quiz

  

Question 1: One of the first Cialis ads aired at the 2004 ________.
Super BowlAmerican Football LeagueNFL on televisionNational Football League

Question 2:
How is Tadalafil excreted?
feces , urine
62% feces / 8% urine
In feces and urine , unchanged drug only 1%
50% urine, 36% feces

Question 3: The most common side effects when using tadalafil are ________, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose.
Tension headacheMigraineHeadacheCluster headache

Question 4: [8] PDE11 is expressed in skeletal muscle, the prostate, the liver, the ________, the pituitary gland, and the testes.
KidneyEndocrine systemImmune systemUrinary system

Question 5: [1][2] In 1993, the Bothell, Washington, biotechnology company ICOS Corporation began studying compound IC351, a phosphodiesterase type 5 (PDE5) ________.
Enzyme kineticsMetabolismEnzyme inhibitorProtein

Question 6: In December 2003, the Food and Drug Administration approved tadalafil (as Cialis) for sale in the United States as the third ED prescription drug pill (after ________ (Viagra) and vardenafil (Levitra)).
AmoxapineBuspironeSildenafilVesnarinone

Question 7: [3] Sildenafil and vardenafil also inhibit ________ more than tadalafil.
Alkaline phosphatasePDE3PDE1Phospholipase A2

Question 8: Cialis was discovered by Glaxo Wellcome (now ________) under a partnership between Glaxo and ICOS to develop new drugs that began in August 1991.
Shire plcGlaxoSmithKlineAstraZenecaVodafone

Question 9: [8] It is thought that the inhibition of PDE1 by sildenafil and vardenafil leads to vasodilation, flushing, and ________.
BradycardiaMyocardial infarctionTachycardiaAtrial fibrillation

Question 10: [7] In the event of a medical emergency, ________ and medical personnel should be notified of any recent doses of tadalafil.
AmbulanceEmergency medical technicianParamedicEmergency medical services
















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