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Tacrolimus: Quiz


Question 1:
What is the chemical name of Tacrolimus (IUPAC)
-4-hydroxy- 3,7-dimethoxy- 17-methylmorphin- 7-en- 6-one
3,4-dimethoxy- 9a-methylmorphinan- 6u03B2,14-diol

Question 2:
How is Tacrolimus excreted?
82% urine; 12% faeces
Mostly faecal
Urine, within 24 hours

Question 3: This FKBP12-FK506 complex interacts with and inhibits ________ thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
CalcineurinPTEN (gene)Ubiquitin carboxy-terminal hydrolase L1Butyrylcholinesterase

Question 4: [1] Like ________, it was found in a soil fungus, although it is produced by a type of bacterium, Streptomyces tsukubaensis.

Question 5: It reduces ________ and interleukin-2 (IL-2) activity.
Cytotoxic T cellT helper cellT cellRegulatory T cell

Question 6: Hatanaka; it was among the first macrolide immunosuppressants discovered, preceded by the discovery of rapamycin (sirolimus) on ________ (Easter Island) in 1975.
Wallis and FutunaEaster IslandFrench PolynesiaNiue

Question 7: Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after allogeneic organ transplant to reduce the activity of the patient's ________ and so lower the risk of organ rejection.
Adaptive immune systemToll-like receptorLymphatic systemImmune system

Question 8: It suppresses inflammation in a similar way to ________, and is equally as effective as a mid-potency steroid.
TestosteroneSteroidLipid metabolismMetabolism

Question 9: Also like ciclosporin it has a wide range of adverse interactions, including that with ________ which increases plasma-tacrolimus concentration.
Orange (fruit)GrapefruitCitrusDietary fiber

Question 10: In recent years, Tacrolimus has been used to suppress the inflammation associated with ulcerative colitis, a form of ________.
Colorectal cancerCoeliac diseaseInflammatory bowel diseaseCrohn's disease

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