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Sulfonylurea: Quiz

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Question 1: Sulfonylureas are used almost exclusively in ________ type 2.
Diabetic retinopathyDiabetes mellitus type 1Diabetes mellitusDiabetic ketoacidosis

Question 2: Sulfonylurea (UK: Sulphonylurea) derivatives are a class of ________ that are used in the management of diabetes mellitus type 2 ("adult-onset").
Anti-diabetic drugBeta blockerDiureticACE inhibitor

Question 3: Sulfonylureas were discovered by the chemist Marcel Janbon and co-workers,[4] who were studying sulfonamide ________ and discovered that the compound sulfonylurea induced hypoglycemia in animals.
Nucleic acid inhibitorAntibioticAntibiotic misuseATC code J01

Question 4: Sulfonylureas are potentially ________ and cannot be used in pregnancy or in patients who may become pregnant.
Valproic acidAcne vulgarisAspirinTeratology

Question 5: Among the second-generation agents Gliclazide and Glimeperide offer the best protection against coronary artery disease while glyburide and glipizide may increase the risk of ________.
Ischaemic heart diseaseMyocardial infarctionAtrial fibrillationHeart failure

Question 6: The rise in intracellular calcium leads to increased fusion of ________ granulae with the cell membrane, and therefore increased secretion of (pro)insulin.
InsulinEndocrine systemGlucagonAdiponectin

Question 7: They act by increasing ________ release from the beta cells in the pancreas.
InsulinGlucagonEndocrine systemAdiponectin







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