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Src (gene): Quiz


Question 1: The protein product is pp60vsrc, a cytoplasmic protein with tyrosine-specific protein kinase activity (EC, that associates with the cytoplasmic face of the ________.
Cell nucleusVesicle (biology)Cell membraneCell (biology)

Question 2: At some point, the normal gene became ________ into an abnormally-functioning oncogene, as is now observed in RSV.
SpeciationEvolutionMutationPopulation genetics

Question 3: Later work by others showed that RSV was a type of ________.
Virus diseaseAdenoviridaeHerpesviridaeRetrovirus

Question 4: v-src is therefore an instructive example of an ________ whereas c-src is a proto-oncogene.
CarcinogenesisOncogeneCancerTumor suppressor gene

Question 5: The Src family includes nine mammalian members: Src, Yes, ________, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.
Abl geneSrc (gene)FYNCD117

Question 6: The protein consists of three domains, an N-terminal SH3 domain, a central ________ and a tyrosine kinase domain.
Janus kinase 2Abl geneGrb2SH2 domain


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