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Solifenacin: Quiz

  

Question 1: Solifenacin is a competitive ________ antagonist.
Histamine H3 receptor5-HT1A receptorMuscarinic acetylcholine receptor5-HT receptor

Question 2: Because of a long elimination half life, a once-a-day dose can offer 24 hour control of the urinary bladder ________ tone.
Smooth muscleIntrafusal muscle fiberSkeletal muscleCardiac muscle

Question 3: Solifenacin is metabolized in the liver by the cytochrome P450 enzyme ________.
CYP2E121-HydroxylaseCYP2D6CYP3A4

Question 4: Therefore, it should not be administered concomitantly with drugs which also have this effect, such as ________ or pimozide.
LevofloxacinCiprofloxacinOfloxacinMoxifloxacin

Question 5: When administered concomitantly with drugs that inhibit CYP3A4, such as ________, the metabolism of solifenacin is impaired, leading to an increase in its concentration in the body and a reduction in its excretion.
KetoconazolePosaconazoleItraconazoleMiconazole

Question 6: It is also contraindicated in long QT syndrome, as solifenacin,like tolterodine and darifenacin, binds to ________ channels and may prolong the QT interval.
TRPM7KvLQT1HERGCystic fibrosis transmembrane conductance regulator

Question 7: The binding of ________ to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
DextromethorphanKynurenic acidKetamineAcetylcholine

Question 8: As all anticholinergics, solifenacin may rarely cause heat prostration due to decreased ________.
PerspirationPotassiumZincIron
















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