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Small interfering RNA: Quiz

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Question 1: ________ of an exogenous siRNA can be problematic because the gene knockdown effect is only transient, particularly in rapidly dividing cells.
Horizontal gene transferTransfectionTransposonOptical transfection

Question 2: Most notably, siRNA is involved in the ________ (RNAi) pathway, where it interferes with the expression of a specific gene.
Model organismArgonautePiwiRNA interference

Question 3: siRNAs have a well-defined structure: a short (usually 21-nt) double strand of ________ (dsRNA) with 2-nt 3' overhangs on either end:
DNANon-coding RNASmall interfering RNARNA

Question 4: One way of overcoming this challenge is to modify the siRNA in such a way as to allow it to be expressed by an appropriate vector, e.g., a ________.
DNABacteriaPlasmidArchaea

Question 5: siRNAs were first discovered by ________'s group at the Sainsbury Laboratory in Norwich, England, as part of post-transcriptional gene silencing (PTGS) in plants.
David BaulcombeCraig MelloCaenorhabditis elegansAndrew Fire

Question 6: Each strand has a 5' ________ group and a 3' hydroxyl (-OH) group.
PhosphateAdenosine triphosphatePhosphate homeostasisPhosphorus

Question 7: [2] This discovery led to a surge in interest in harnessing RNAi for ________ and drug development.
Animal testingClinical trialMedical researchEpidemiology

Question 8: In 2008, a team of researchers from Texas Tech University and ________ announced the development of a siRNA-based treatment that may ultimately counteract the Human Immunodeficiency Virus (HIV).
Brown UniversityHarvard CrimsonRutgers UniversityHarvard University

Question 9: In 2008 a novel DNA-siRNA delivery system that could lead to more efficient and more disease-specific vaccines against infectious diseases was developed by researchers at The ________.
University of FloridaTexas A&M UniversityUniversity of Texas at AustinTexas Tech University

Question 10: This structure is the result of processing by dicer, an ________ that converts either long dsRNAs or small hairpin RNAs into siRNAs.
Cofactor (biochemistry)ProteinEnzymeEnzyme inhibitor







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