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Serine protease: Quiz

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Question 1: The triad is a coordinated structure consisting of three essential ________: histidine (His 57), serine (Ser 195) (hence the name "serine protease") and aspartic acid (Asp 102).
MetabolismAmino acid synthesisAmino acidL-DOPA

Question 2: The combination of these three enzymes make an incredibly effective digestive team and are primarily responsible for the digestion of ________.
MyosinMetabolismProteinActin

Question 3: The serine has an -OH group that is able to act as a ________, attacking the carbonyl carbon of the scissile peptide bond of the substrate.
NitrogenBromineOxygenNucleophile

Question 4: The best-studied serpins are antithrombin and alpha 1-antitrypsin, studied for their role in coagulation/thrombosis and emphysema/________ respectively.
Heparin cofactor IIAlpha 1-antitrypsinAlpha 2-antiplasminAlpha 1-antichymotrypsin

Question 5: ________ levels may be required in the diagnosis of hemorrhagic or thrombotic conditions.
PlateletFibrinolysisTissue plasminogen activatorCoagulation

Question 6: The polypeptide substrate binds to the surface of the serine protease enzyme such that scissile bond is inserted into the active site of the enzyme, with the carbonyl carbon of this bond positioned near the ________ serine.
BromineNucleophileOxygenNitrogen

Question 7: Preferred residues include phenylalanine, tryptophan, and tyrosine, which fit into a snug ________ pocket.
Chemical polaritySuperhydrophobeHydrophileHydrophobe

Question 8: All three of these enzymes are similar in structure, as shown through their ________.
X-ray crystallographyCrystallographyAtomProtein

Question 9: Serine protease site of the ________ (WUSTL)
Stanford UniversityCarnegie Mellon UniversityWashington University in St. LouisDuke University

Question 10: Serum ________ is used in prostate cancer screening, risk stratification, and post-treatment monitoring.
PlasminFactor XProstate-specific antigenReelin







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