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Saxitoxin: Quiz


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Question 1: The predicted reaction sequence of suggested SxtA, based on its primary structure, is the loading of the ACP with acetate from acetyl-CoA, followed by SxtA-catalyzed ________ of acetyl-ACP, which is then converted to propionyl-ACP.
MethylationAmino acidPosttranslational modificationAcetylation

Question 2: Saxitoxin (STX) is a neurotoxin naturally produced by certain species of marine ________ (Alexandrium sp., Gymnodinium sp., Pyrodinium sp.

Question 3: Later another SxtA performs a Claisen condensation reaction between propionyl-ACP and ________ producing 4.
ArginineCysteineGlutamic acidLysine

Question 4: [9] The ________ involved in the biosynthesis of STX have not been identified by previous studies.
ProteinEnzyme inhibitorCofactor (biochemistry)Enzyme

Question 5: The dinoflagellate Pyrodinium bahamense is the source of STX found in ________.
North CarolinaMassachusettsFloridaNew Jersey

Question 6: Saxitoxin synthesis is the first non-terpene alkaloid pathway described for ________.
Gram-negative bacteriaCorynebacteriumBacteriaGram-positive bacteria

Question 7: ) and cyanobacteria (Anabaena sp., some Aphanizomenon spp., ________ sp., Lyngbya sp., Planktothrix sp.).

Question 8: STX has been found in at least 12 marine and freshwater ________ species in Asia.

Question 9: In the United States, paralytic shellfish poisoning is limited to ________ and the West Coast.
Midwestern United StatesNortheastern United StatesNew EnglandSouthern United States

Question 10: Although STX biosynthesis seems complex, organisms from the two kingdoms, species of marine dinoflagellates and freshwater cyanobacteria, are capable of making these toxins by the same ________.
MetabolismAmino acidLipid metabolism3-hydroxy-3-methylglutaryl-CoA lyase


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