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Robertsonian translocation: Quiz


Question 1: During a Robertsonian translocation, the participating chromosomes break at their ________ and the long arms fuse to form a single chromosome with a single centromere.
KaryotypeCentromereChromosomal translocationHeterochromatin

Question 2: The most frequent forms of Robertsonian translocations are between chromosomes 13 and 14, 13 and 21, and 21 and 22, and occur when the long arms of two acrocentric chromosomes fuse at the ________ and the two short arms are lost.
CentromereChromosomal translocationHeterochromatinKaryotype

Question 3: Robertsonian translocation is a common form of chromosomal rearrangement that in humans occurs in the five acrocentric ________ pairs, namely 13, 14, 15, 21, and 22.
Chromosomal translocationChromosomeAutosomeKaryotype

Question 4: Genetic counseling and ________ is offered to families that may be carriers of chromosomal translocations.
CancerDNAGenetic discriminationGenetic testing

Question 5: [2] However, the progeny of this carrier may inherit an unbalanced trisomy 21, causing ________.
Turner syndromeXYY syndromeTrisomy 18Down syndrome

Question 6: In unbalanced forms, Robertsonian translocations cause chromosomal deletions or addition and result in syndromes of multiple malformations, including trisomy 13 (Patau syndrome) and trisomy 21 (________).
Turner syndromeTrisomy 18Down syndromeXYY syndrome

Question 7: Common Robertsonian translocations are confined to the acrocentric chromosomes 13, 14, 15, 21 and 22, because the short arms of these chromosomes encode for ________ which is present in multiple copies.
Transfer RNARibosomal RNANon-coding RNADNA

Question 8: They are named after the American ________ geneticist W.


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