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Reboxetine: Quiz

  
  

Question 1: According to Weiss et al., reboxetine is an intermediate-level inhibitor of ________, which gives it the potential to interact with ciclosporin, tacrolimus, paroxetine, sertraline, quinidine, fluoxetine, fluvoxamine.
Band 3RHAGABCG2P-glycoprotein

Question 2: Unlike most antidepressants on the market, reboxetine is a ________ (NRI); it does not inhibit the reuptake of serotonin, therefore it can be safely combined with an SSRI.
Norepinephrine reuptake inhibitorMonoamine oxidase inhibitorNorepinephrine-dopamine reuptake inhibitorMirtazapine

Question 3: Therefore it is yet to be available in the ________.
CanadaUnited StatesAlaskaPhilippines

Question 4: 2-Benzylpiperidine4-BenzylpiperidineDesoxypipradrolDiphemethoxidineEthylphenidateMethylnaphthidateMethylphenidate (________) • NocainePhacetoperanePipradrolSCH-5472
LisdexamfetamineDexmethylphenidateMethamphetamineAmphetamine

Question 5: Adaphenoxate • Adapromine • ________Bromantane • Chlodantane • Gludantane • Memantine • Midantane
PhencyclidineKetamineDizocilpineAmantadine

Question 6: By mid-2007, reboxetine was licensed worldwide in over 50 countries, including Italy, ________ and the United Kingdom.
NetherlandsPolandGreeceGermany

Question 7: Both the (R,R)-(–) and (S,S)-(+)-enantiomers of reboxetine are predominantly metabolized by the ________ isoenzyme.
CYP3A421-HydroxylaseCYP2E1CYP2D6

Question 8: Because of its reliance on CYP3A4, reboxetine O-desethylation is markedly inhibited by papaverine and ________.
KetoconazolePosaconazoleMiconazoleItraconazole

Question 9: Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD, developed by Pharmacia (now ________).
Johnson & JohnsonMerck & Co.PfizerAmerican Express

Question 10: Anatoxin-aBicucullineDMCMFlurothylGabazinePentetrazolPicrotoxinStrychnine________
ThujoneEthanol1,4-ButanediolPregabalin
















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