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Pyruvate kinase deficiency: Quiz


Question 1: Treatment can include a ________ or removal of the spleen.
Intraoperative blood salvageTransfusion reactionBlood transfusionBlood donation

Question 2: Micro-: ________ (Plummer-Vinson syndrome)
Serum ironHenoch–Schönlein purpuraIron deficiency anemiaSickle-cell disease

Question 3: This will cause a "right shift" in the ________ oxygen saturation curve, implying a decreased oxygen affinity for the hemoglobin and earlier oxygen unloading than under normal conditions.
Serum ironArterial blood gasGlycated hemoglobinHemoglobin

Question 4: Erythrocytes manufacture ATP through ________.
GluconeogenesisCarbohydrate metabolismGlycolysisMetabolism

Question 5: The lysis of the RBCs leads to hemolytic anemia and may cause jaundice from increased ________.
HaptoglobinBilirubinReference ranges for blood testsHemoglobin

Question 6: Pyruvate kinase deficiency is the second most common cause of enzyme-deficient hemolytic anemia, following ________.
Sideroblastic anemiaGlucose-6-phosphate dehydrogenase deficiencyHaemophilia BHaemophilia A

Question 7: Both autosomal dominant[2] and ________[3] inheritance have been observed with the disorder; classically, and more commonly, the inheritance is autosomal recessive.
AlleleDominance (genetics)DNAChromosome

Question 8: A variety of mutations can lead to lowered production, activity, or stability of pyruvate kinase, an ________ essential to glycolysis.
ProteinEnzymeEnzyme inhibitorCofactor (biochemistry)

Question 9: Pyruvate kinase deficiency, also called erythrocyte pyruvate kinase deficiency,[1] is an inherited ________ of the enzyme pyruvate kinase which affects the survival of red blood cells and causes them to deform into echinocytes on peripheral blood smears.
Pancreatic diseaseFumarase deficiencyInborn error of metabolismICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases

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