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Pyrazinamide: Quiz

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Question 1: Pyrazinamide is a ________ and is available in a wide variety of presentations.
Food and Drug Administration (United States)Clinical trialDr. Reddy's LaboratoriesGeneric drug

Question 2: Other side effects include nausea and vomiting, anorexia, sideroblastic anemia, skin rash, urticaria, pruritus, hyperuricemia, dysuria, interstitial nephritis, malaise; rarely porphyria, and ________.
HeadacheFeverFatigue (medical)Influenza-like illness

Question 3: Pyrazinamide in conjunction with rifampin is a preferred treatment for ________.
Iron overloadHyperuricemiaElevated alkaline phosphataseLatent tuberculosis

Question 4: tuberculosis has the enzyme pyrazinamidase which is only active in ________ conditions.
Acid–base reactionOxygenAcid dissociation constantAcid

Question 5: [1] Pyrazinamide is removed by ________ and therefore doses should always be given at the end of a dialysis session.
ICD-9-CM Volume 3SurgeryHemodialysisHemofiltration

Question 6: The most dangerous side effect of pyrazinamide is ________, which is dose related.
HepatotoxicityAspirinAcute liver failureHepatitis

Question 7: Pyrazinoic acid was thought to inhibit the enzyme ________ I, which is required by the bacterium to synthesise fatty acids[7] although this has been discounted.
Fatty acid synthaseMitochondrial trifunctional proteinHADHBHADHA

Question 8: In particular, it is not used to treat other mycobacteria; ________ and Mycobacterium leprae are innately resistant to pyrazinamide.
Mycobacterium avium aviumMycobacterium bovisMycobacterium ulceransMycobacterium fortuitum

Question 9: It is metabolised by the ________ and the metabolic products are excreted by the kidneys.
PancreasLiverEndocrine systemImmune system

Question 10: Pyrazinamide is a prodrug that stops the growth of ________.
CorynebacteriumMycobacterium tuberculosisMycobacterium lepraeClostridium difficile







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