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Protein C: Quiz


Question 1: The protein C pathway’s key enzyme, activated protein C, provides physiologic antithrombotic activity and exhibits both ________ and anti-apoptotic activities.
AnalgesicAnxiolyticAnti-inflammatoryNon-steroidal anti-inflammatory drug

Question 2: The PROC gene is located on the second ________ (2q13-q14).
AutosomeChromosomeKaryotypeChromosomal translocation

Question 3: ________ is acquired protein C deficiency due to treatment with the vitamin K inhibitor anticoagulant warfarin.
Factor XWarfarin necrosisHeparinCoagulation

Question 4: [4][5] It also plays a role in the development of thrombosis and ________.
Cerebral venous sinus thrombosisSubarachnoid hemorrhageStrokeCerebral aneurysm

Question 5: It is used in the treatment of severe sepsis, septic shock and ________.
Idiopathic thrombocytopenic purpuraThrombocytopenic purpuraThrombotic thrombocytopenic purpuraDisseminated intravascular coagulation

Question 6: The best known and most common hereditary form is ________.
Factor V LeidenHaemophiliaThrombophiliaAntiphospholipid syndrome

Question 7: If homozygous, this presents with a form of ________ in newborns termed purpura fulminans; it is treated by replacing the defective protein C.
Thrombotic thrombocytopenic purpuraIdiopathic thrombocytopenic purpuraThrombocytopenic purpuraDisseminated intravascular coagulation

Question 8: It is a vitamin K-dependent serine protease ________ (EC that is activated by thrombin into activated protein C (APC).
EnzymeAdenosine triphosphateEnzyme inhibitorCofactor (biochemistry)

Question 9: ________(activated) is recombinant activated protein C from Eli Lilly Co, USA.
ClopidogrelDrotrecogin alfaAspirinArgatroban

Question 10: The activated form (with ________ and phospholipid as a cofactor) degrades Factor Va and Factor VIIIa.
Protein SProtein CPlasminTissue factor

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