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Proteasome: Quiz


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Question 1: ________, a molecule developed by Millennium Pharmaceuticals and marketed as Velcade, is the first proteasome inhibitor to reach clinical use as a chemotherapy agent.

Question 2: The inner two rings are made of seven β subunits that contain the six ________ active sites.
Cysteine proteaseSerine proteaseAspartate proteaseProtease

Question 3: [18] The extent to which substrates must be unfolded before translocation is not known, but substantial tertiary structure, and in particular nonlocal interactions such as ________, are sufficient to inhibit degradation.
MethylationDisulfide bondAmino acidPeptide bond

Question 4: Each catalytic β subunit also possesses a conserved ________ residue required for proteolysis.

Question 5: However, some cell lines — in particular, primary cultures of quiescent and differentiated cells such as thymocytes and ________ — are prevented from undergoing apoptosis on exposure to proteasome inhibitors.
Nervous systemGlial cellNeuronPhotoreceptor cell

Question 6: [16] Alternative β forms denoted β1i, β2i, and β5i can be expressed in hematopoietic cells in response to exposure to pro-inflammatory signals such as ________, in particular, interferon gamma.

Question 7: [48] In vertebrate cells, "slippage" through the mitotic checkpoint leading to premature ________ exit can occur despite the delay of this exit by the spindle checkpoint.
Cell cyclePreprophaseMeiosisMitosis

Question 8: [58] The ability of proteasome inhibitors to induce apoptosis in rapidly dividing cells has been exploited in several recently developed chemotherapy agents such as ________ and salinosporamide A.

Question 9: [2] Proteins are tagged for degradation with a small protein called ________.
UbiquitinProtein biosynthesisPhosphorylationAmino acid

Question 10: [1] The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a ________ that breaks peptide bonds.
HydrogenNitrogenChemistryChemical reaction


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