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Prostacyclin: Quiz


Question 1: Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular ________ between the two hormones in relation to vascular damage.
HomeostasisClaude BernardComputational neuroscienceCybernetics

Question 2: PGI2 is derived from the ω-6 ________.
Eicosapentaenoic acidProstaglandinArachidonic acidEicosanoid

Question 3:
What is the chemical name of Prostacyclin (IUPAC)
7-chloro- 1-methyl- 5-phenyl- 1,3-dihydro- 2H- 1,4-benzodiazepine- 2-thione
-5-[-5-hydroxy-4-hexahydro-2H-cyclopentabfuran-2-ylidene]pentanoic acid

Question 4: as a ________ in severe Raynaud's phenomenon or ischemia of a limb;
AntianginalVasodilationBeta blockerCalcium channel blocker

Question 5: Through innovative work done by researcher Lucy Clapp, treprostinil has demonstrated a unique effect on ________ gamma, a transcription factor important in vascular pathogenesis as a mediator of proliferation, inflammation and apoptosis.
Estrogen receptorLiver X receptorNuclear receptorPeroxisome proliferator-activated receptor

Question 6: This allows NSAIDs to result in PGI2 dominance that promotes circulation and retards ________.
ThrombosisCerebral venous sinus thrombosisDeep vein thrombosisLymphedema

Question 7: Prostacyclin is produced in endothelial cells from prostaglandin H2 (PGH2) by the action of the ________ prostacyclin synthase.
ProteinEnzymeEnzyme inhibitorCofactor (biochemistry)

Question 8: Since thromboxane (an ________ stimulator of platelet aggregation ) is also downstream of COX enzymes, one would think that the effect of NSAIDs would balance out.
LeukotrieneProstaglandinEicosanoidArachidonic acid

Question 9: Prostacyclin (or PGI2) is a member of the family of lipid molecules known as ________.
EicosanoidLeukotrieneArachidonic acidProstaglandin

Question 10: coumarins: Acenocoumarol • Coumatetralyl • Dicoumarol (Dicumarol) • Ethyl biscoumacetate • Phenprocoumon • ________


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