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Prion: Quiz


Question 1: [25] Maglio and colleagues have shown that mice without the genes for normal cellular PrP protein have altered hippocampal ________.
MemoryLong-term potentiationNervous systemLong-term depression

Question 2: A ________ for the normal protein has been identified: the PRNP gene.

Question 3: The ________ recommends any of the following three procedures for the sterilization of all heat-resistant surgical instruments to ensure that they are not contaminated with prions:
World Health OrganizationFood and Agriculture OrganizationUniversal Postal UnionSwitzerland

Question 4: Several topological forms exist; one cell surface form anchored via glycolipid and two ________ forms.
Peripheral membrane proteinMembrane receptorIntegral membrane proteinTransmembrane protein

Question 5: The human prion disease variant Creutzfeldt-Jakob disease, however, is believed to be caused by a prion which typically infects cattle, causing ________ and is transmitted through infected meat.
CanadaUnited KingdomUnited StatesBovine spongiform encephalopathy

Question 6: No virus particles, bacteria, or fungi have been conclusively associated with prion diseases, although ________ has been known to be associated with infectious, yet non-lethal prions, such as Sup35p.
FungusProteinSaccharomyces cerevisiaeYeast

Question 7: Examples include ________, caustic soda, and strong acidic detergents such as LpH.
BleachHydrogen peroxideOzoneChlorine

Question 8: In January 2007, she and her colleagues published an article reporting to have found a ________ in 10%, or less, of their scrapie-infected cells in culture.
AdenoviridaeRotavirusVirusHerpes simplex virus

Question 9: This was initially controversial as it contradicts the so-called "________," which describes nucleic acid as the central form of replicative information.
Central dogma of molecular biologyPost-transcriptional regulationRegulation of gene expressionEpigenetics

Question 10: Mammalian prion classification International Committee on Taxonomy of Viruses – ________
Biological classificationBioinformaticsInternational Committee on Taxonomy of VirusesVirus classification

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