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Pramipexole: Quiz

  

Question 1:
What is the chemical name of Pramipexole (IUPAC)
-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
9,10-didehydro- N-propyl- D-lysergamide
9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-
4-[3-propyl]-1-piperazinethanol

Question 2: Dizziness, lightheadedness, or fainting, especially when standing up (________)
Aortic dissectionHypertensionOrthostatic hypotensionPulmonary hypertension

Question 3:
What is the elimination half life of Pramipexole?
8 hrs
8-12 hours
7-8 hours
1.2-2 hr

Question 4:
How is Pramipexole excreted?
0,11-0,13
10-15% unchanged
Urine , Feces
Biliary, renal

Question 5: Pramipexole acts as a selective non-ergoline D2, D3, and D4 ________ receptor full agonist (see dopamine agonist) with highest affinity by 5-fold for D3.
DopamineTyramineAmphetaminePhenethylamine

Question 6: [1] Pramipexole has shown robust effects on pilot studies in a placebo-controlled proof of concept study in ________.
Major depressive disorderBipolar disorderSchizoaffective disorderMania

Question 7: When dopamine is released, it may activate ________ in the striatum, which is another component of the basal ganglia.
Dopamine receptorD1-like receptorDopamine receptor D2D2-like receptor

Question 8: [2] It is also being investigated for the treatment of ________ and fibromyalgia.
Major depressive disorderSchizoaffective disorderMood disorderBipolar disorder

Question 9: Parkinson's disease is a neurodegenerative disease affecting the substantia nigra, a component of the ________.
Basal gangliaCingulate cortexObsessive–compulsive disorderStriatum

Question 10: The substantia nigra has a high quantity of dopaminergic neurons, which are nerve cells that release the neurotransmitter known as ________.
DopamineTyramineAmphetaminePhenethylamine
















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