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Platelet: Quiz

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Question 1: Megakaryocyte and platelet production is regulated by thrombopoietin, a hormone usually produced by the liver and ________.
Endocrine systemImmune systemKidneyUrinary system

Question 2: ________, CAD and myocardial infarction, MI
Ischaemic heart diseaseCardiovascular diseaseHeart failureCoronary artery disease

Question 3: Drug-induced thrombocytopenic purpura (for example ________ (HIT))
Heparin-induced thrombocytopeniaHenoch–Schönlein purpuraAntiphospholipid syndromeParoxysmal nocturnal hemoglobinuria

Question 4: When the platelets contact collagen or vWF, they are activated.  They are also activated by ________ (formed with the help of tissue factor).
Tissue plasminogen activatorFactor XThrombinPlasmin

Question 5: Platelets are produced in blood cell formation (thrombopoiesis) in ________, by budding off from megakaryocytes.
Hematopoietic stem cellBone marrowLymphatic systemImmune system

Question 6: They circulate in the ________ of mammals and are involved in hemostasis, leading to the formation of blood clots.
PlateletRed blood cellBloodBlood plasma

Question 7: Platelet activation further results in the scramblase-mediated transport of negatively-charged phospholipids to the platelet surface.  These phospholipids provide a catalytic surface (with the charge provided by ________ and phosphatidylethanolamine) for the tenase and prothrombinase complexes.
DipalmitoylphosphatidylcholinePlatelet-activating factorPhosphatidic acidPhosphatidylserine

Question 8: α-granules (containing platelet factor 4, transforming growth factor-β1, platelet-derived growth factor, fibronectin, B-thromboglobulin, vWF, fibrinogen, and ________ V and XIII).
FibrinolysisCoagulationTissue plasminogen activatorUrokinase

Question 9: For example, immune ________ and thrombocytosis (high counts) may lead to thrombosis, although this is mainly when the elevated count is due to myeloproliferative disorder.
Paroxysmal nocturnal hemoglobinuriaHenoch–Schönlein purpuraHeparin-induced thrombocytopeniaAntiphospholipid syndrome

Question 10: delta granules (containing ADP or ATP, ________, and serotonin)
CalciumIronAluminiumMagnesium







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