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Piribedil: Quiz


Question 1: ________ antagonist, subtypes α2a and α2c: could be the reason why piribedil seems to cause less drowsiness than other dopamine agonists.
Dopamine receptorAdrenergic receptorAlpha-1 adrenergic receptorAlpha-2 adrenergic receptor

Question 2: Minor gastrointestinal upset (nausea, vomiting, flatulence, etc) in predisposed individuals, or when taken between meals: adjust dosage individually, and/or add ________ (Motilium).

Question 3: ________ agonist, selective for subtypes D2 and D3.
Dopamine receptorDopamine receptor D2D1-like receptorD2-like receptor

Question 4: ________ or drowsiness may occur, particularly in predisposed individuals (underlying condition or causative illness).
Pulmonary hypertensionHypertensionAortic dissectionOrthostatic hypotension

Question 5: Anhedonia and treatment-resistant depression in unipolar and bipolar ________ (off label).
Bipolar disorderMood disorderSchizoaffective disorderMajor depressive disorder

Question 6: Treatment of Parkinson's disease (PD), either as monotherapy (without ________ (Levodopa)) or in combination with L-DOPA therapy, in the early stages as well as in the advanced stages of the disease.

Question 7: Piribedil (trade names Trivastal, Pronoran, Trastal, Trivastan) is a piperazine derivative and selective ________ D2 and D3 receptor agonist with additional α2-adrenergic antagonist properties.

Question 8: Treatment of pathological cognitive deficits in the elderly (impaired ________, motivation, memory, etc).
Cognitive psychologyExecutive functionsAttentionPerception

Question 9: Adjuvant treatment in intermittent claudication due to ________ (PVD) of the lower limbs (stage 2).
Peripheral vascular diseaseAtheromaAtherosclerosisBuerger's disease

Question 10: Lack of affinity to ________ 5-HT2B: theoretically no risk of heart valve impairment.
5-HT1A receptor5-HT2C receptor5-HT receptor5-HT2A receptor


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