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Pick's disease: Quiz


Question 1: Pick's disease is named after Arnold Pick, a professor of psychiatry from the University of Prague who first discovered and described the disease in 1892 by examining the brain tissue of several deceased patients with histories of ________.
DementiaAlzheimer's diseaseHuntington's diseaseParkinson's disease

Question 2: Patient died from acute ________ with "sudden death" 6 months after this presentation.
Ischaemic heart diseaseHeart failureMyocardial infarctionCoronary artery disease

Question 3: Other regions that are involved include the caudate, which is severely affected, the dorsomedial region of the ________, the globus pallidus, and locus cerulus.
PutamenHippocampusBasal gangliaSubstantia nigra

Question 4: Strangely, the ________ is most often uninvolved or only mildly involved, but cases of extreme degeneration do exist.
White matterSubstantia nigraGrey matterStriatum

Question 5: Frontotemporal Dementia Information Page from the ________
National Institutes of HealthNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Institute of Neurological Disorders and Stroke

Question 6: For more information on Pick's Disease, see the article on the pathologic process of frontotemporal lobar degeneration (FTLD) and its related clinical syndromes of ________, semantic dementia, and progressive nonfluent aphasia.
Huntington's diseaseParkinson's diseaseFrontotemporal dementiaAlzheimer's disease

Question 7: [4] Hematoxylin and eosin staining allows visualization of another population of Pick cells, which are both tau and ________ protein negative.
Amino acidPhosphorylationUbiquitinProtein biosynthesis

Question 8: Frontotemporal dementia information and videos from the ________ Memory and Aging Center
University of California, Los AngelesUniversity of California, Hastings College of the LawUniversity of California, BerkeleyUniversity of California, San Francisco

Question 9: [3] A variety of stains can aid in the visualization of Pick bodies and Pick cells, but immunohistochemical staining using anti-tau and anti-ubiquitin ________ have proven the most efficient and specific.
AntibodyAdaptive immune systemImmune systemAutoantibody

Question 10: In addition, the presence of neurofibrillary tangles that are a hallmark of Alzheimer’s can be stained with antibodies to ________, amyloid P, and heparan sulfate glycosaminoglycan.
Insulin-like growth factor 1Basic fibroblast growth factorEpidermal growth factorTGF beta 1

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