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Pethidine: Quiz


Question 1: Like other opioid drugs, pethidine has the potential to cause physical dependence or ________.
Drug addictionBenzodiazepine dependenceAddictionSocial anxiety disorder

Question 2: [1] Pethidine exerts its analgesic effects by the same mechanism as ________, by acting as an agonist at the μ-opioid receptor.

Question 3:
How is Pethidine excreted?

Question 4:
What is the chemical name of Pethidine (IUPAC)
Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
ethyl 1-2-(2-hydroxyethoxy)ethyl-4-phenylpiperidine-4-carboxylate
ethyl 1-2-(oxolan-2-ylmethoxy)ethyl-4-phenylpiperidine-4-carboxylate

Question 5: [7] Pethidine also has stimulant effects mediated by its inhibition of the ________ transporter (DAT) and norepinephrine transporter (NAT).

Question 6: Pethidine has been shown to be less effective than morphine, ________ or hydromorphone at easing severe pain, or pain associated with movement or coughing.

Question 7: Pethidine's efficacy as an analgesic was discovered almost accidentally; it was synthesized in 1939 at an ________ laboratory as an antimuscarinic agent.
IG FarbenIG Farben TrialMonowitz concentration campBayer

Question 8: [4] Several countries, including ________, have put strict limits on its use.
CanadaAustraliaUnited KingdomBarbados

Question 9: Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as its hydrochloride salt in tablets, as a syrup, or by intramuscular or ________.
Intravenous therapyDosage formIntramuscular injectionRoute of administration

Question 10: In addition to its strong opioidergic and anticholinergic effects, it has ________ activity related to its interactions with sodium ion channels.
Beta blockerLocal anestheticAnticonvulsantCalcium channel blocker

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