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Pentylenetetrazol: Quiz

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Question 1: [2] The mechanism of the ________ action of pentylenetetrazol at the cellular neuronal level is still unclear.
EpilepsyLafora diseasePartial seizureGeneralised epilepsy

Question 2: Specifically, hamsters denied their natural ________ (though not denied sleep) had their memory restored to near-normal levels when treated with pentylenetetrazol.
Circadian rhythmMelatoninChronobiologySuprachiasmatic nucleus

Question 3: [4] These results caused renewed interest in pentylenetetrazol as a potential drug candidate for ________, although clinical trials are probably still a couple of years away.
XYY syndromeTrisomy 18Turner syndromeDown syndrome

Question 4: ________ studies have shown it acts at cell membrane level decreasing the recovery time between action potentials by increasing potassium permeability of the axon.
ElectrophysiologyNeuroscienceBrainNeuron

Question 5: Pentylenetetrazol is also a prototypical anxiogenic drug and, has been extensively utilized in animal models of ________.
EmotionMental confusionHostilityAnxiety

Question 6: Other studies have implicated an increase in membrane currents of several other ions, such as sodium and ________, leading to an overall increase in excitability of the neuron membrane.
CalciumAluminiumIronMagnesium

Question 7: It has been used in shock therapy, but was never considered to be effective, and side-effects such as ________ were difficult to avoid.
SeizureConvulsionICD-10 Chapter XVIII: Symptoms, signs and abnormal clinical and laboratory findingsSymptom

Question 8: Several classes of compounds can modulate the pentylenetetrazol discriminative stimulus including 5-HT1A, 5-HT3, NMDA, ________, and L-type calcium channel ligands.
GlycineSerineAlanineGlutamic acid

Question 9: In 1939, pentylenetetrazol was replaced by ________ as the preferred method for inducing seizures in England's mental hospitals.
PsychosisElectroconvulsive therapyDSM-IV CodesPsychiatry







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