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Norepinephrine transporter: Quiz


Question 1: The norepinephrine transporter or NET (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the ________ norepinephrine (noradrenaline) from the synapse back to its vesicles for storage until later use.

Question 2: Certain ________ medications act to raise noradrenaline, such as the SNRIs and the tricyclic antidepressants (TCAs).

Question 3: The Ala457Pro rare missense mutation results in a loss of function and has been associated with orthostatic intolerance (associated with ________) in one kindred.
Vasovagal episodeOrthostatic hypotensionDysautonomiaPostural orthostatic tachycardia syndrome

Question 4: The SNPs rs3785143 and rs11568324 have been related to the ________.
Attention-deficit hyperactivity disorderSchizophreniaBipolar disorderMajor depressive disorder

Question 5: T-182C (rs2242446), a ________ variant
PromoterProkaryotic transcriptionTranscription (genetics)DNA

Question 6: There are several variations in the gene,[3] e.g., these ________ (SNP):
RNASingle-nucleotide polymorphismDNAGenetics

Question 7: It also appears to transport the neurotransmitter ________ in the same way, but to a lesser degree.

Question 8: NET is 617 amino acids in length, contains 12 transmembrane domains,[1] and is encoded by the SLC6A2 ________.


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