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Nifedipine: Quiz

  
  

Question 1:
How is Nifedipine excreted?
85% of single oral dose is elimiated with 5 days - Urine, and Feces
Renal: >50%, Biliary: 5-15%
Feces 5-10%
95% Biliary, 5% Renal

Question 2:
What is the chemical name of Nifedipine (IUPAC)
-ethyl methyl 2,6-dimethyl-4--1,4-dihydropyridine-3,5-dicarboxylate
3,7-dimethyl-1--3,7-dihydro-1H-purine-2,6-dione
2,6-dichloro-N-, benzene-1,4-diamine
3,5-dimethyl 2,6-dimethyl-4--1,4-dihydropyridine-3,5-dicarboxylate

Question 3: ________ (fast heart rate) may occur as a reaction.
BradycardiaMyocardial infarctionTachycardiaAtrial fibrillation

Question 4:
What is the molecular weight of Nifedipine?
209.24 g/mol
346.335 g/mol
359.4
301.72438 g/mol

Question 5: In hypertension, recent clinical guidelines generally favour diuretics and ________, although calcium channel antagonists are still favoured as primary treatment for older black patients.
Angiotensin II receptor antagonistRenin inhibitorACE inhibitorAntihypertensive drug

Question 6:
What is the melting point of Nifedipine?
90
110
173
216

Question 7: There are several possible mechanisms, including the lowering of ________ activity.
CYP2E1CYP2D6CYP3A421-Hydroxylase

Question 8: The approved uses for nifedipine are the long-term treatment of hypertension (high blood pressure) and ________.
AtherosclerosisCoronary artery diseaseMyocardial infarctionAngina pectoris

Question 9: Topical nifedipine has been shown to be as effective as topical nitrates for ________.
Anal fissureConstipationCrohn's diseaseAchalasia

Question 10: Extended release formulations of nifedipine should be taken on an empty stomach, and patients are warned not to consume anything containing ________ or grapefruit juice, as they raise blood nifedipine levels.
Dietary fiberGrapefruitOrange (fruit)Citrus
















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