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NMDA receptor: Quiz

  

Question 1: A positive change in ________ will make it more likely that the ion channel in the NMDA receptor will open by expelling the Mg2+ ion that blocks the channel from the outside.
Action potentialNeuronMembrane potentialResting potential

Question 2: Each subunit has an extensive cytoplasmic domain, which contain residues that can be directly modified by a series of ________ and protein phosphatases, as well as residues that interact with a large number of structural, adaptor, and scaffolding proteins.
GlucokinaseTyrosine kinaseProtein kinaseAspartokinase

Question 3: Whereas NR2B is predominant in the early postnatal brain, the number of NR2A subunits grows, and eventually ________ subunits outnumber NR2B.
NMDA receptor5-HT receptor5-HT3 receptorGlutamate receptor

Question 4: NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as ________.
ExcitotoxicityAlzheimer's diseaseGlutamate receptorGlutamic acid

Question 5: One study suggests that ________ may play a role in the NMDA receptor maturation by increasing the NR2B subunit mobility.
Prostate-specific antigenCathepsin GSerine proteaseReelin

Question 6: They contain the binding-site for the neurotransmitter ________.
DizocilpineGlutamineGlutamic acidNitrous oxide

Question 7: This property is fundamental to the role of the NMDA receptor in memory and learning, and it has been suggested that this channel is a biochemical substrate of ________, where it can act as a coincidence detector for membrane depolarization and synaptic transmission.
Nikolaas TinbergenHebbian theoryAnimal echolocationCaridoid escape reaction

Question 8: Reelin modulates NMDA function through Src family kinases and ________.
ASPM (Gene)LDL receptorDAB1Low density lipoprotein receptor-related protein 8

Question 9: [12] In addition, NMDARs also require the binding of the co-agonist ________ for the efficient opening of the ion channel, which is a part of this receptor.
Glutamic acidAlanineGlycineSerine

Question 10: Antagonists of the NMDA receptor are used as ________ for animals and sometimes humans, and are often used as recreational drugs due to their hallucinogenic properties, in addition to their unique effects at elevated dosages such as dissociation.
General anaestheticLocal anestheticDepressantAnesthetic
















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