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Multiple endocrine neoplasia type 2b: Quiz


Question 1: [4] 95% of patients with MEN 2B have a single-point mutation of the ________ allele, which suppresses cancer formation.
CD117RET proto-oncogeneSrc (gene)Epidermal growth factor receptor

Question 2: [6] When adrenal cancer is present, serum levels of vanillylmandelic acid are increased and the ratio of ________ to norepinephrine is skewed.

Question 3: [6] The mutation - a single ________ to threonine substitution in the intracellular tyrosine kinase domain - alters the substrate specificity of intracellular signal transduction,[7] conferring dominant cancer-causing activity.
MethionineCysteineGlutamic acidAlanine

Question 4: It is the most severe type of ________,[2] differentiated by the presence of oral and submucosal tumors in addition to endocrine tumors.
Multiple endocrine neoplasiaMultiple endocrine neoplasia type 2bMultiple endocrine neoplasia type 1Multiple endocrine neoplasia type 2

Question 5: A variety of ________ have been proposed for MEN 2B, such as Williams-Pollock syndrome, Gorlin-Vickers syndrome, and Wagenmann-Froboese syndrome.
DoriansJulius CaesarEponymScientific phenomena named after people

Question 6: ________ almost always occurs, and cancer of the adrenal glands (pheochromocytoma) occurs in 50% of cases.
Medullary thyroid cancerFollicular thyroid cancerAdrenocortical carcinomaNeuroblastoma

Question 7: adrenal cortex (Adrenocortical adenoma, ________)
InsulinomaGlucagonomaAdrenocortical carcinomaMultiple endocrine neoplasia

Question 8: Identifying a mutated ________ indicates a greater than 90% probability of developing multiple mucosal neuromata.
RET proto-oncogeneCD117Epidermal growth factor receptorSrc (gene)

Question 9: Like MEN 1 and MEN 2A, MEN 2B is inherited as an ________ trait, which means affected people have one affected parent, and possibly-affected siblings and children.
Dominance (genetics)AlleleGeneticsGene

Question 10: Benign tumors (neoplasms) develop in the mouth, eyes, and submucosa of almost all organs in the first decade of life,[4] followed by ________ and thyroid tumors after puberty.
OvaryAdrenal glandEndocrine systemTesticle


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