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Multiple endocrine neoplasia type 2: Quiz


Question 1: adrenal cortex (Adrenocortical adenoma, ________)
InsulinomaAdrenocortical carcinomaMultiple endocrine neoplasiaGlucagonoma

Question 2: Most cases of MEN2 derive from a variation in the ________, and are specific for cells of neural crest origin.
CD117Epidermal growth factor receptorRET proto-oncogeneSrc (gene)

Question 3: ________, parathyroid, and adrenals), but may also occur in endocrine tissues of organs not classically thought of as endocrine.
Endocrine systemTesticleThyroidOvary

Question 4: The protein produced by the RET gene plays an important role in the ________ (transforming growth factor beta) signaling system.
TGF beta 2TGF betaTGF beta 3TGF beta 1

Question 5: Sotos announced his hypothesis that Abraham Lincoln, the 16th President of the United States (________1865), had MEN 2B.
18611948November 1March 4

Question 6: Other diseases, such as ________, result from loss-of-function variants.
Pancreatic diseaseHirschsprung's diseaseSchatzki ringPyloric stenosis

Question 7: MEN2A is additionally characterized by the presence of ________ or tumor.
GlucagonParathyroid hormoneEndocrine systemCalcitonin

Question 8: MEN2 can present with a sign or symptom related to a tumor or, in the case of ________, with characteristic musculoskeletal and/or lip and/or gastrointestinal findings.
Hypothalamic hamartomaEndocrine systemMultiple endocrine neoplasia type 2bMultiple endocrine neoplasia type 1

Question 9: The tumors may be benign or malignant (________).

Question 10: MEN2 is a sub-type of MEN (________) and itself has sub-types, as discussed below.
Multiple endocrine neoplasia type 1Multiple endocrine neoplasiaMultiple endocrine neoplasia type 2Multiple endocrine neoplasia type 2b


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