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Morpholino: Quiz

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Question 1: In ________ organisms, pre-mRNA is transcribed in the nucleus, introns are spliced out, then the mature mRNA is exported from the nucleus to the cytoplasm.
FungusEukaryotePlantProtist

Question 2: Morpholinos block small (~25 base) regions of the base-pairing surfaces of ribonucleic acid (________).
RNADNASmall interfering RNANon-coding RNA

Question 3: Gene Tools, LLC and AVI BioPharma Inc. claim ________ on aspects of Morpholino oligos.
Intellectual propertyShariaHuman rightsLaw

Question 4: Morpholino oligomers (oligos) are an antisense technology used to block access of other molecules to specific sequences within ________.
DNANucleic acidNucleic acid analoguesRNA

Question 5: [28] Morpholinos do not activate toll-like receptors and so they do not activate innate immune responses such as interferon induction or the NF-κB mediated ________ response.
VasculitisLeukocyte extravasationInflammationMeningitis

Question 6: For a Morpholino to be effective, it must be delivered past the ________ into the cytosol of a cell.
Cell nucleusCell (biology)Vesicle (biology)Cell membrane

Question 7: In molecular biology, a Morpholino is a molecule used to modify ________.
DNARNAGene expressionProtein

Question 8: [29] Most of these effects have been shown to be due to activation of p53-mediated ________, and can be suppressed by co-injection of an anti-p53 Morpholino along with the experimental Morpholino.
Apoptosis-inducing factorApoptosisTranscription factorSignal transduction

Question 9: Developmental biologists inject Morpholino oligos into eggs or embryos of zebrafish,[9] African clawed frog (Xenopus),[10], ________,[11] and killifish (F.
Sea urchinSquidSturgeonHerring

Question 10: Structurally, the difference between Morpholinos and ________ is that while Morpholinos have standard nucleic acid bases, those bases are bound to morpholine rings instead of deoxyribose rings and linked through phosphorodiamidate groups instead of phosphates.
RNAProteinDNAGene







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