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Mineralocorticoid: Quiz


Question 1: The effects of mineralocorticoids are mediated by slow genomic mechanisms through ________ as well as by fast nongenomic mechanisms through membrane-associated receptors and signaling cascades.
Transcription factorNuclear receptorEstrogen receptorAndrogen receptor

Question 2: Aldosterone and ________ (a glucosteroid) have similar affinity for the mineralocorticoid receptor; however, glucocorticoids circulate at roughly 100 times the level of mineralocorticoids.

Question 3: 18OH-DOC is deeply involved in one of the three forms (at least) of ________ (high blood pressure).
HypertensionAortic dissectionAtherosclerosisEssential hypertension

Question 4: This in turn results in an increase of ________ and blood volume.
Renin-angiotensin systemBlood pressureCirculatory systemVasodilation

Question 5: Important mineralocorticoid inhibitors are ________ and eplerenone.

Question 6: Antihypertensives • Diuretics • Vasodilators • Beta blockers • Calcium channel blockers • renin-angiotensin system (________, Angiotensin II receptor antagonists, Renin inhibitors)
ACE inhibitorAntihypertensive drugChemotherapyATC code L

Question 7: The hormone receptor without ligand binding interacts with ________ and prevents the transcription of targeted genes.
Hsp90HSPA1BHeat shock proteinChaperone (protein)

Question 8: The primary endogenous mineralocorticoid is ________, although a number of other endogenous hormones (including progesterone and deoxycorticosterone) have mineralocorticoid function.

Question 9: 18 hydroxy 11 deoxycorticosterone (also designated 18OH-DOC) is a steroid hormone probably used to conserve ________ and stimulate hydrogen ion (or acid) excretion.

Question 10: ________ and edema due to excessive Na+ and water retention.
Essential hypertensionAtherosclerosisHypertensionAortic dissection


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