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Methadone: Quiz

  
  
  

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Question 1: [13] Naloxone is preferred to the newer, longer acting antagonist ________.
NaltrexoneHydromorphoneMethadoneBuprenorphine

Question 2:
What is the elimination half life of Methadone?
24-36 h
22 - 24 hs
1.6-59 hours , 25-36 hours
36-39 hours

Question 3: Its main ________ is oral.
Intramuscular injectionIntravenous therapyDosage formRoute of administration

Question 4:
How is Methadone excreted?
Urine, Test by specific gravity and bilirubin
45% excreted unchanged in urine
In urine
primarily urine

Question 5:
What is the chemical name of Methadone (IUPAC)
5-chloro-6'-methyl-3-4-(methylsulfonyl)phenyl-
-6--4,4-diphenylheptan-3-one
4-[amino]-2,6-bisphenol
5-(1R,2S,3S,5S)-3--8-methyl-8-azabicyclo3.2.1octan-2-yl]-3--1,2-oxazole

Question 6: Another close relative of methadone is ________, first marketed in 1957 under the trade name of Darvon.
DextropropoxypheneTramadolMethorphanMorphanol

Question 7: The most common ________ at a methadone clinic is in a racemic oral solution, though in Germany, only the (R)-methadone enantiomer has traditionally been used, as it is responsible for most of the desired opioid effects.
Route of administrationIntramuscular injectionIntravenous therapyDosage form

Question 8: Other drugs which are not structurally related to methadone are also used in maintenance treatment, particularly Subutex (________) and Suboxone (buprenorphine combined with naloxone).
BuprenorphineHydromorphoneDihydrocodeineTramadol

Question 9: Glutamate is the primary excitatory ________ in the CNS.
NeuromodulationOxytocinDopamineNeurotransmitter

Question 10: The racemic hydrochloride is the only form available in most countries, such as the Netherlands, ________, France and in the United States as of March 2008.
BelgiumDenmarkUnited KingdomSpain
















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