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Mesalazine: Quiz


Question 1:
What is the elimination half life of Mesalazine?
~5-8 hours
5 hours after initial dose.
5 to 9 hours
5-14 hours

Question 2:
What is the chemical name of Mesalazine (IUPAC)
5-amino-2-hydroxybenzoic acid
2-2-(4-chlorophenyl)-1,3-benzoxazol-5-ylpropanoic acid

Question 3: Preparations that lower stool pH (such as ________, a laxative) will affect the binding of mesalazine in the bowel and will therefore reduce its efficacy.

Question 4: Antibiotics (Neomycin, Nystatin, Natamycin, Streptomycin, Polymyxin B, Paromomycin, ________, Kanamycin, Vancomycin, Colistin, Rifaximin)
MiconazoleMetronidazoleClotrimazoleAmphotericin B

Question 5: ________ agents, excluding corticosteroids (Cromoglicic acid)
AllergenCell-mediated immunityImmune systemAutoimmunity

Question 6: Hypersensitivity reactions (including rash, ________ aka hives, interstitial nephritis and lupus erythematosus-like syndrome)
UrticariaContact dermatitisAtopic dermatitisSystemic lupus erythematosus

Question 7: Mesalazine is formulated for oral ingestion as tablets or granules, and for rectal administration as a rectal suppository, suspension or ________.
Injection (medicine)EnemaIntraperitoneal injectionDosage form

Question 8: corticosteroids acting locally (Prednisolone, ________, Prednisone, Betamethasone, Tixocortol, Budesonide, Beclometasone)

Question 9: As a derivative of salicylic acid, 5-ASA is also thought to be an ________ that traps free radicals, which are potentially damaging byproducts of metabolism.
NutritionAntioxidantHuman nutritionOxidative stress

Question 10: Blood disorders (including agranulocytosis, ________, leukopenia, neutropenia, thrombocytopenia)
Thrombotic thrombocytopenic purpuraIdiopathic thrombocytopenic purpuraAplastic anemiaAnemia

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