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Mefloquine: Quiz

  

Question 1:
How is Mefloquine excreted?
Primarily bile and feces; urine
Primarily Hepatic and Biliary
Primarily feces, urine 10-20%
Primarily through the bile, urinary

Question 2: "In areas where ________ and mefloquine are equally effacious in preventing malaria, doxycycline is the drug of choice.
ClindamycinDoxycyclineMinocyclineMetronidazole

Question 3:
What is the elimination half life of Mefloquine?
15 to 30 minutes
4 to 5 hours
2 to 4 weeks
5-6 hours

Question 4:
What is the chemical name of Mefloquine (IUPAC)
Methyl 2-cyano-3,12-dioxooleana-1,9dien-28-oate
3u03B2-, lup-20- en-28-oic acid
2,3,4,5-tetrahydro-2,8-dimethyl-5--1H-pyridoindole
-2,8-bisquinolin-4-yl]-methanol

Question 5:
What is the molecular weight of Mefloquine?
358.842 g/mol
318.449 g/mol
378.312 g/mol
266.381 g/mol

Question 6: Mefloquine is an orally administered ________ used prophylactically against and as a treatment for malaria.
ClindamycinChloroquineAntimalarial drugQuinine

Question 7: According to the Center for Disease Control and Prevention (CDC) guidelines to prevent malaria, Mefloquine is no longer the drug of choice to treat malaria (and it is not necessarily the best drug to prevent malaria) caused by chloroquine-resistant ________.
Plasmodium falciparumPlasmodium vivaxPlasmodium ovalePlasmodium malariae

Question 8: In the 1990s, reports appeared in the media[3] saying that the drug may have played a role in the ________, which involved the torture and murder of a Somali citizen in the custody of Canadian peacekeeping troops.
Jean Chr├ętienSomalia AffairDoug YoungThe Canadian Airborne Regiment

Question 9: Connexins in the brain are believed to play a role in movement, vision and ________, likely due to a role in the synchronization of neural activity.
MemoryKC (patient)Cognitive psychologyNeuropsychology

Question 10: In 2004, researchers found that mefloquine in adult mice blocks ________ called Cx36 and Cx50.
ConnexinPore-forming toxinDefensinMembrane receptor
















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