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Loperamide: Quiz


Question 1:
What is the elimination half life of Loperamide?
9.1 to 14.4 hours
15 to 30 minutes
10u201328 hours
3 to 6 hours in amniotic fluid, less than 1 minute in blood plasma

Question 2: coli O157:H7 or ________, loperamide is contraindicated.

Question 3:
What is the molecular weight of Loperamide?
494.525 g/mol
234.380 g/mol
269.345 g/mol
477.037 g/mol

Question 4: It works by decreasing the activity of the myenteric plexus, which, like ________, decreases the tone of the longitudinal smooth muscles but increases tone of circular smooth muscles of the intestinal wall.

Question 5: Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors in the myenteric plexus large intestines; by itself it does not affect the ________ like other opioids.
Grey matterWhite matterCentral nervous systemNeuron

Question 6: Loperamide molecules do not cross the blood-brain barrier in significant amounts, and, thus, it has no ________ or euphoric properties.
AnalgesicStimulantDissociativeNon-steroidal anti-inflammatory drug

Question 7: [7] Treatment is not recommended for patients that could suffer detrimental effects from rebound ________.
Ulcerative colitisConstipationCrohn's diseaseIrritable bowel syndrome

Question 8: Treatment should be avoided in the presence of ________ or if the stool is bloody (dysentery).
HeadacheFeverInfluenza-like illnessFatigue (medical)

Question 9: [7] It is of no value in diarrhoea caused by ________, Shigella or Campylobacter.
CholeraTyphoid feverVibrio choleraePlague (disease)

Question 10: Any that do cross the blood-brain barrier are quickly exported from the brain by ________ (Pgp), also known as multidrug resistance protein (MDR1).
RHAGABCG2Band 3P-glycoprotein

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