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Lisdexamfetamine: Quiz

  

Question 1:
What is the chemical name of Lisdexamfetamine (IUPAC)
N--N′,N′-dimethyl-N-pyridin-2-ylethane-1,2-diamine
7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
N-(1S)-1-methyl-2-phenylethyl--lysinamide
1,2-benzisoxazole-3-methanesulfonamide

Question 2:
What is the molecular weight of Lisdexamfetamine?
263.378 g/mol
146.091 kDa
270.714
209.24 g/mol

Question 3: The inhibition leads to potentiation of amphetamine's effects, resulting in the increased release of ________ and other monoamines from the adrenergic nerve endings.
PhenethylamineNorepinephrineTyramineOctopamine

Question 4: Amphetamines may slow the intestinal absorption of ________ and may also produce an enhanced and synergistic anticonvulsant action.
PrimidonePhenytoinLorazepamDiazepam

Question 5: Adaphenoxate • Adapromine • ________Bromantane • Chlodantane • Gludantane • Memantine • Midantane
KetamineDizocilpineAmantadinePhencyclidine

Question 6:
How is Lisdexamfetamine excreted?
Renal 40%, biliary 60%
Renal 11%, faecal 78%
Renal: ~2%
Renal, faecal

Question 7: Amphetamines may enhance the activity of tricyclic antidepressants, with some tricyclic drugs there may be a significant and sustained increase in the concentration of amphetamine in the brain along with increased ________ activity and effects.
Myocardial infarctionHeartFetal circulationCirculatory system

Question 8: Lisdexamfetamine itself is inactive and acts as a prodrug to ________ upon cleavage of the lysine portion of the molecule.
DextroamphetamineMethamphetamineSelegilineMethylphenidate

Question 9:
What is the elimination half life of Lisdexamfetamine?
sibutramine approx. 1 hourMetabolite 1: 14 hoursMetabolite 2: 16 hours
1-1.5 hours
Approximately 1 hour
< 1 hour

Question 10: Either drug could be useful in treating amphetamine poisoning[3], and may also be useful for toxicity caused by other phenethylamines such as ________, 4-Fluoromethamphetamine, phentermine, etc.
MethyloneMethylenedioxyphenethylamineMDMAMethoxymethylenedioxyphenethylamine
















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