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Leukotriene: Quiz


Question 1: Leukotrienes assist in the pathophysiology of ________, causing or potentiating the following symptoms:
Allergic bronchopulmonary aspergillosisHypersensitivity pneumonitisFarmer's lungAsthma

Question 2: During cysteinyl leukotriene interaction, they can stimulate proinflammatory activities such as endothelial cell adherence and chemokine production by ________.
Basophil granulocyteEosinophil granulocyteWhite blood cellMast cell

Question 3: The lipoxygenase pathway is active in leukocytes, including mast cells, ________, neutrophils, monocytes, and basophils.
PhagocyteEosinophil granulocyteNeutrophil granulocyteBasophil granulocyte

Question 4: The name leukotriene, introduced by Swedish biochemist Bengt Samuelsson in 1979, comes from the words ________ and triene (indicating the compound's three conjugated double bonds).
Neutrophil granulocytePhagocyteWhite blood cellEosinophil granulocyte

Question 5: Cysteinyl leukotriene receptors CysLT1 and CysLT2 are present on mast cells, ________ and endothelial cells.
Neutrophil granulocyteEosinophil granulocyteBasophil granulocytePhagocyte

Question 6: In cells that express LTC4 synthase, such as mast cells and eosinophils, LTA4 is conjugated with the tripeptide ________ to form the first of the cysteinyl-leukotrienes, LTC4.
GlutathioneAdenosine triphosphateEthanolMethionine

Question 7: Leukotrienes are produced in the body from ________ by the enzyme 5-lipoxygenase.
Arachidonic acidEicosanoidEicosapentaenoic acidProstaglandin

Question 8: Leukotrienes are synthesized in the cell from arachidonic acid by ________.
Arachidonate 5-lipoxygenaseCyclooxygenaseGamma-glutamyl transpeptidasePhospholipase A2

Question 9: Leukotrienes act principally on a subfamily of ________.
Olfactory receptorG protein-coupled receptorMembrane receptorReceptor (biochemistry)

Question 10: The catalytic mechanism involves the insertion of an oxygen moiety at a specific position in the ________ backbone.
Eicosapentaenoic acidProstaglandinArachidonic acidEicosanoid


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