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Lassa fever: Quiz

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Question 1: Clinically, Lassa fever infections are difficult to distinguish from other viral hemorrhagic fevers such as ________ and Marburg, and from more common febrile illnesses such as malaria.
West Nile virusYellow feverEbolaDengue fever

Question 2: Researchers at the ________ facility, where military biologists study infectious diseases, have a promising vaccine candidate.
United States Army Medical Research Institute of Infectious DiseasesBiological warfare2001 anthrax attacksBiosafety level

Question 3: Lassa virus is zoonotic (transmitted from animals), in that it spreads to man from ________, specifically multi-mammate rats (Mastomys natalensis).
RodentSpalacidaeSquirrelCricetidae

Question 4: Transmission through ________ has also been observed.
Infant formulaImmune systemBreastfeedingBreast milk

Question 5: Non-specific symptoms include fever, facial swelling, and muscle fatigue, as well as ________ and mucosal bleeding.
ScleritisDacryoadenitisUveitisConjunctivitis

Question 6: Siga Technologies is developing an ________ that has been shown effective in treating experimentally infected guinea pigs.
VaccineAntibioticATC code J05Antiviral drug

Question 7: Lassa fever is an acute viral hemorrhagic fever first described in 1969 in the town of Lassa, in Borno State, Nigeria located in the Yedseram river valley at the south end of ________.
Dead SeaLake TurkanaGreat Salt LakeLake Chad

Question 8: The virus shares a receptor – alpha-dystroglycan (alpha-DG) a versatile receptor for proteins of the ________ – with the prototypic arenavirus lymphocytic choriomeningitis virus.
CollagenElastic fiberExtracellular matrixHistology

Question 9: Once within the cell the viruses are rapidly delivered to ________ via vesicular trafficking albeit one that is largely independent of the small GTPases Rab5 and Rab7.
Vesicle (biology)Cell (biology)EndosomeCell membrane

Question 10: ________ for antigen and IgM antibodies gives 88% sensitivity and 90% specificity for the presence of the infection.
ImmunoprecipitationELISAImmunoassayImmunohistochemistry







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