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Irinotecan: Quiz

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Question 1:
What is the chemical name of Irinotecan (IUPAC)
8-azabicyclo3.2.1octane
9-yl-1,4u2019bipiperidine-1u2019-carboxylate
2,3'-bipyridine
3--2-methyl-1H-indol-5-ol

Question 2:
What is the elimination half life of Irinotecan?
~12 h
6 to 12 hours
12 to 35 hours
12 to 36 hours

Question 3:
What is the molecular weight of Irinotecan?
162.19
677.185 g/mol
494.525 g/mol
321.456 g/mol

Question 4:
How is Irinotecan excreted?
?
in feces
Biliary and renal
0,11-0,13

Question 5: This is reflected in dramatically lowered white blood cell counts in the blood, in particular the ________.
GranulocyteNeutrophil granulocyteEosinophil granulocytePhagocyte

Question 6: halogenated/ribonucleotide reductase inhibitors (________, Clofarabine, Fludarabine)
MethotrexatePentostatinCladribineBortezomib

Question 7: This includes the regimen FOLFIRI which consists of infusional ________, leucovorin, and irinotecan.
FluorouracilCyclophosphamideMethotrexatePemetrexed

Question 8: Its main use is in ________, particularly in combination with other chemotherapy agents.
Colorectal cancerCrohn's diseaseHepatocellular carcinomaStomach cancer

Question 9: Irinotecan (Camptosar, ________; Campto, Yakult Honsha) is a drug used for the treatment of cancer.
Johnson & JohnsonMerck & Co.PfizerAmerican Express

Question 10: Chemically, it is a semisynthetic analogue of the natural alkaloid ________.
CamptothecinCyclophosphamideDoxorubicinMethotrexate







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