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Ion channel: Quiz

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Question 1: It was then shown more directly with an electrical recording technique known as the "________," which led to a Nobel Prize to Erwin Neher and Bert Sakmann, the technique's inventors.
Action potentialPatch clampIon channelNeuron

Question 2: Both α and β subunits are extensively ________.
Amino acidProtein biosynthesisGlycosylationUbiquitin

Question 3: ________ is caused by mutations in the CFTR gene, which is a chloride channel.
PneumoniaMalignant hyperthermiaCoeliac diseaseCystic fibrosis

Question 4: ________ (EA), characterized by sporadic bouts of severe discoordination with or without myokymia, and can be provoked by stress, startle, or heavy exertion such as exercise.
Hartnup diseaseEpisodic ataxiaGenetic disorderCystinuria

Question 5: Because "voltage-activated" channels underlie the ________ and because "transmitter-activated" channels mediate conduction across the synapses, channels are especially prominent components of the nervous system.
Ion channelAction potentialNeuronPhotoreceptor cell

Question 6: ________ (GEFS+)
Generalized epilepsy with febrile seizures plusParamyotonia congenitaErythromelalgiaCentral core disease

Question 7: ________ is a ventricular arrhythmia syndrome caused by mutations in one or more of presently ten different genes, most of which are potassium channels and all of which affect cardiac repolarization.
Jervell and Lange-Nielsen syndromeAndersen–Tawil syndromeRomano-Ward syndromeLong QT syndrome

Question 8: ________ (PC) and potassium aggravated myotonias (PAM)
Hyperkalemic periodic paralysisCentral core diseaseParamyotonia congenitaHypokalemic periodic paralysis

Question 9: ________, is used by cone snails to hunt prey.
Beta-BungarotoxinConotoxinAlpha-BungarotoxinEpibatidine

Question 10: Most of what researchers have deduced about channel operation so far they have established through electrophysiology, ________, gene sequence comparison and mutagenesis.
MetabolismProteinAmino acidBiochemistry







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