Integrin: Quiz

Question 1: If it emerges ________ from the membrane, the ligand binding site would apparently be obstructed, especially as integrin ligands are typically massive, and well cross-linked components of the ECM.
OrthogonalityEigenvalue, eigenvector and eigenspaceEuclidean vectorVector space

Question 2: Integrins are of vital importance to all ________ and have been found in all animals investigated, from sponges to mammals.

Question 3: In mammals, 18 α and 8 β subunits have been characterized, whereas the ________ genome encodes only five α and two β subunits, and the Caenorhabditis nematodes possess two α and one β genes.
MaizeModel organismDrosophila melanogasterDrosophila

Question 4: A prominent function of the integrins is seen in the molecule GPIIbIIIa, an integrin on the surface of blood ________ (thrombocytes) responsible for cross-linking platelets in fibrin within a developing blood clot.
CoagulationRed blood cellBlood plasmaPlatelet

Question 5: Integrins work alongside other proteins such as ________, cell adhesion molecules and selectins to mediate cell-cell and cell-matrix interaction and communication.

Question 6: Despite these wide-ranging efforts, the ________ crystal structure obtained for the complete extracellular region of one integrin, αvβ3 was a surprise.
Nuclear fusionIonizing radiationRadiation therapyX-ray

Question 7: An acidic amino acid features in the integrin-interaction site of many ECM proteins, for example, as part of the amino acid sequence ________-Glycine-Aspartic acid ("RGD" in the one-letter amino acid code).
CysteineArginineLysineGlutamic acid

Question 8: One of the most important functions of surface integrins is their role in ________.
Cell migrationCell membraneCell nucleusAntibody

Question 9: When released from the substrate, integrin molecules are taken back into the cell by ________; they are transported through the cell to its front by the endocytic cycle where they are added back to the surface.
EfferocytosisPhagocytosisEndocytosisReceptor-mediated endocytosis

Question 10: These act by regulating kinases such as FAK (focal adhesion kinase) and ________ family members to phosphorylate substrates such as p130CAS thereby recruiting signaling adaptors such as CRK.
CD117HER2/neuEpidermal growth factor receptorSrc (gene)

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