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Imipramine: Quiz


Question 1:
What is the chemical name of Imipramine (IUPAC)

Question 2:
What is the elimination half life of Imipramine?
1.6-59 hours , 25-36 hours
1.1-2 hours
11 u00B1 4 days
11-25 hours

Question 3: At the advent of ________, its sometimes intolerable side-effect profile became less tolerable.
Tricyclic antidepressantMirtazapineSerotonin reuptake inhibitorSelective serotonin reuptake inhibitor

Question 4: Regarding dopamine uptake, imipramine is far less potent than most other antidepressants (for example, it is 1/20 the potency of ________ and paroxetine, see references).
TrimipramineTricyclic antidepressantAmitriptylineTetracyclic antidepressant

Question 5: ________ and jaundice (yellowing of the skin and/or whites of the eyes) have been reported in isolated cases.

Question 6: Imipramine, a ________, affects numerous neurotransmitter systems known to be involved in the etiology of depression, anxiety , ADD/ADHD, enuresis and numerous other mental and physical conditions.

Question 7: BDNF Brain derived neurotrophic factor (________) is implicated in neurogenesis in the hippocampus, and studies suggest that depressed patients have decreased levels of BDNF and reduced hippocampal neurogenesis.
MelatoninNeurotrophin-3Nerve growth factorBrain-derived neurotrophic factor

Question 8: The mechanisms of Imipramine's medicinal action include, but are not limited to, effects on: norepinephrine, serotonin, dopamine, epinephrine, sigma receptor, enkephalinase, histamine, muscarine, and ________.
AcetylcholineKynurenic acidDextromethorphanKetamine

Question 9: Imipramine (sold as Antideprin, Deprimin, Deprinol, Depsonil, Dynaprin, Eupramin, Imipramil, Irmin, Janimine, Melipramin, Surplix, Tofranil) is an ________ medication, a tricyclic antidepressant of the dibenzazepine group.

Question 10: Imipramine has additional indications for the treatment of panic attacks, chronic pain, and ________.
HypersomniaNarcolepsyKleine-Levin syndromeOndine's curse

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